15,405 research outputs found
A FAMILY OF CATION ATPASE-LIKE MOLECULES FROM PLASMODIUM-FALCIPARUM
Abstract. We report the nucleotide and derived amino acid sequence of the ATPase 1 gene from Plasmodium falciparum. The amino acid sequence shares homology with the family of "P-type cation transloeating ATPases in conserved regions important for nucleotide binding, conformational change, or phosphorylation. The gene, which is present on chromosome 5, has a product longer than any other reported for a P-type ATPase. Interstrain analysis from 12 parasite isolates by the polymerase chain reaction reveals that a 330-bp nucleotide sequence encoding three cytoplasmic regions conserved in cation ATPases (regions a-c) is of constant length. By contrast, another 360-bp sequence which is one of four regions we refer to as
Deviation from one-dimensionality in stationary properties and collisional dynamics of matter-wave solitons
By means of analytical and numerical methods, we study how the residual
three-dimensionality affects dynamics of solitons in an attractive
Bose-Einstein condensate loaded into a cigar-shaped trap. Based on an effective
1D Gross-Pitaevskii equation that includes an additional quintic self-focusing
term, generated by the tight transverse confinement, we find a family of exact
one-soliton solutions and demonstrate stability of the entire family, despite
the possibility of collapse in the 1D equation with the quintic self-focusing
nonlinearity. Simulating collisions between two solitons in the same setting,
we find a critical velocity, , below which merger of identical in-phase
solitons is observed. Dependence of on the strength of the transverse
confinement and number of atoms in the solitons is predicted by means of the
perturbation theory and investigated in direct simulations. Symmetry breaking
in collisions of identical solitons with a nonzero phase difference is also
shown in simulations and qualitatively explained by means of an analytical
approximation.Comment: 10 pages, 7 figure
Implementation of a Standardized Handoff System for a General Surgery Residency Program
Introduction:
The I-PASS Handoff Bundle is an evidence based standardized set of educational materials designed to decrease handoff failures in patient care.
Two of every three sentinel events , the most serious events reported to the Joint Commission, are due to failures of communication, including miscommunication during patient care handoffs.
Implementation of the I-PASS method results in decreased medical errors and preventable adverse events
There are few studies that evaluate this validated method in the context of a General Surgery resident program
We aim to implement the I-PASS system into the transition of care process for General Surgery residents at our institution, and to analyze of the quality of the handoff process before and after the implementation.https://jdc.jefferson.edu/patientsafetyposters/1047/thumbnail.jp
Absorbing systematic effects to obtain a better background model in a search for new physics
This paper presents a novel approach to estimate the Standard Model
backgrounds based on modifying Monte Carlo predictions within their systematic
uncertainties. The improved background model is obtained by altering the
original predictions with successively more complex correction functions in
signal-free control selections. Statistical tests indicate when sufficient
compatibility with data is reached. In this way, systematic effects are
absorbed into the new background model. The same correction is then applied on
the Monte Carlo prediction in the signal region. Comparing this method to other
background estimation techniques shows improvements with respect to statistical
and systematical uncertainties. The proposed method can also be applied in
other fields beyond high energy physics
A power-law distribution of phase-locking intervals does not imply critical interaction
Neural synchronisation plays a critical role in information processing,
storage and transmission. Characterising the pattern of synchronisation is
therefore of great interest. It has recently been suggested that the brain
displays broadband criticality based on two measures of synchronisation - phase
locking intervals and global lability of synchronisation - showing power law
statistics at the critical threshold in a classical model of synchronisation.
In this paper, we provide evidence that, within the limits of the model
selection approach used to ascertain the presence of power law statistics, the
pooling of pairwise phase-locking intervals from a non-critically interacting
system can produce a distribution that is similarly assessed as being power
law. In contrast, the global lability of synchronisation measure is shown to
better discriminate critical from non critical interaction.Comment: (v3) Fixed error in Figure 1; (v2) Added references. Minor edits
throughout. Clarified relationship between theoretical critical coupling for
infinite size system and 'effective' critical coupling system for finite size
system. Improved presentation and discussion of results; results unchanged.
Revised Figure 1 to include error bars on r and N; results unchanged; (v1) 11
pages, 7 figure
F_B from moving B mesons
We show results for the B meson decay constant calculated both for B mesons
at rest and those with non-zero momentum and using both the temporal and
spatial components of the axial vector current. It is an important check of
lattice systematic errors that all these determinations of f_B should agree. We
also describe how well different smearings for the B meson work at non-zero
momentum - the optimal smearing has a narrow smearing for the b quark.Comment: Lattice2001(heavyquark
Supernovae versus Neutron Star Mergers as the Major r-Process Sources
I show that recent observations of r-process abundances in metal-poor stars
are difficult to explain if neutron star mergers (NSMs) are the major r-process
sources. In contrast, such observations and meteoritic data on Hf182 and I129
in the early solar system support a self-consistent picture of r-process
enrichment by supernovae (SNe). While further theoretical studies of r-process
production and enrichment are needed for both SNe and NSMs, I emphasize two
possible direct observational tests of the SN r-process model: gamma rays from
decay of r-process nuclei in SN remnants and surface contamination of the
companion by SN r-process ejecta in binaries.Comment: 5 pages, to appear in ApJ
Neural Network Parametrization of Deep-Inelastic Structure Functions
We construct a parametrization of deep-inelastic structure functions which
retains information on experimental errors and correlations, and which does not
introduce any theoretical bias while interpolating between existing data
points. We generate a Monte Carlo sample of pseudo-data configurations and we
train an ensemble of neural networks on them. This effectively provides us with
a probability measure in the space of structure functions, within the whole
kinematic region where data are available. This measure can then be used to
determine the value of the structure function, its error, point-to-point
correlations and generally the value and uncertainty of any function of the
structure function itself. We apply this technique to the determination of the
structure function F_2 of the proton and deuteron, and a precision
determination of the isotriplet combination F_2[p-d]. We discuss in detail
these results, check their stability and accuracy, and make them available in
various formats for applications.Comment: Latex, 43 pages, 22 figures. (v2) Final version, published in JHEP;
Sect.5.2 and Fig.9 improved, a few typos corrected and other minor
improvements. (v3) Some inconsequential typos in Tab.1 and Tab 5 corrected.
Neural parametrization available at http://sophia.ecm.ub.es/f2neura
The r-Process Enriched Low Metallicity Giant HD 115444
New high resolution, very high signal-to-noise spectra of ultra-metal-poor
(UMP) giant stars HD 115444 and HD 122563 have been gathered with the
High-Resolution Echelle Spectrometer of the McDonald Observatory 2.7m
Telescope. With these spectra, line identification and model atmosphere
analyses have been conducted, emphasizing the neutron-capture elements. Twenty
elements with Z > 30 have been identified in the spectrum of HD 115444. This
star is known to have overabundances of the neutron-capture elements, but it
has lacked a detailed analysis necessary to compare with nucleosynthesis
predictions. The new study features a line-by-line differential abundance
comparison of HD 115444 with the bright, well-studied halo giant HD 122563. For
HD 115444, the overall metallicity is [Fe/H]~ -3.0. The abundances of the light
and iron-peak elements generally show the same pattern as other UMP stars (e.g.
overdeficiencies of manganese and chromium, overabundances of cobalt), but the
differential analysis indicates several nucleosynthesis signatures that are
unique to each star.Comment: To Appear in the Astrophysical Journa
Measurement of Electron Trapping in the CESR Storage Ring
The buildup of low-energy electrons has been shown to affect the performance
of a wide variety of particle accelerators. Of particular concern is the
persistence of the cloud between beam bunch passages, which can impose
limitations on the stability of operation at high beam current. We have
obtained measurements of long-lived electron clouds trapped in the field of a
quadrupole magnet in a positron storage ring, with lifetimes much longer than
the revolution period. Based on modeling, we estimate that about 7% of the
electrons in the cloud generated by a 20-bunch train of 5.3 GeV positrons with
16-ns spacing and population survive longer than 2.3 s in a
quadrupole field of gradient 7.4 T/m. We have observed a non-monotonic
dependence of the trapping effect on the bunch spacing. The effect of a witness
bunch on the measured signal provides direct evidence for the existence of
trapped electrons. The witness bunch is also observed to clear the cloud,
demonstrating its effectiveness as a mitigation technique.Comment: 6 pages, 9 figures, 28 citation
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